DIAPH1 anticorps (AA 1039-1153)

N° du produit ABIN7599652

Cet anticorps Lapin Polyclonal détecte spécifiquement DIAPH1 dans WB, IF, ELISA, ICC et FACS. Il présente une réactivité envers Humain et Singe.

Aperçu rapide pour DIAPH1 anticorps (AA 1039-1153) (ABIN7599652)

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Reactivité: Humain, Singe

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp DIAPH1 est non-conjugé

Application: Western Blotting (WB), Immunofluorescence (IF), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Détail du produit anti-DIAPH1 anticorps

Épitope: AA 1039-1153

Fonction: Anti-DIAPH1 Antibody Picoband®

Réactivité croisée (Details): No cross-reactivity with other proteins.

Attributs du produit: Anti-DIAPH1 Antibody Picoband® (ABIN7599652). Tested in ELISA, Flow Cytometry, IF, ICC, WB applications. This antibody reacts with Human, Monkey. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Purification: Immunogen affinity purified.

Immunogène: E.coli-derived human DIAPH1 recombinant protein (Position: D1039-Q1153).

Isotype: IgG

Information d'application

Indications d'application: Western blot, 0.25-0.5 μg/mL, Human, Monkey
Immunocytochemistry/Immunofluorescence, 5 μg/mL, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/mL, -
1. Al-Maawali, A., Barry, B. J., Rajab, A., El-Quessny, M., Seman, A., Coury, S. N., Barkovich, A. J., Yang, E., Walsh, C. A., Mochida, G. H., Stoler, J. M. Novel loss-of-function variants in DIAPH1 associated with syndromic microcephaly, blindness, and early onset seizures. Am. J. Med. Genet. 170A: 435-440, 2016. 2. Carreira, S., Goodall, J., Denat, L., Rodriguez, M., Nuciforo, P., Hoek, K. S., Testori, A., Larue, L., Goding, C. R. Mitf regulation of Dia1 controls melanoma proliferation and invasiveness. Genes Dev. 20: 3426-3439, 2006. 3. Ercan-Sencicek, A. G., Jambi, S., Franjic, D., Nishimura, S., Li, M., El-Fishawy, P., Morgan, T. M., Sanders, S. J., Bilguvar, K., Suri, M., Johnson, M. H., Gupta, A. R., Yuksel, Z., Mane, S., Grigorenko, E., Picciotto, M., Alberts, A. S., Gunel, M., Sestan, N., State, M. W. Homozygous loss of DIAPH1 is a novel cause of microcephaly in humans. Europ. J. Hum. Genet. 23: 165-172, 2015.

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Stock: 4 °C,-20 °C

Stockage commentaire: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Détails sur DIAPH1

Antigène: DIAPH1 (Diaphanous Homolog 1 (DIAPH1))

Autre désignation: DIAPH1

Sujet:

Synonyms: Adrenocorticotropic hormone receptor,ACTH receptor,ACTH-R,Adrenocorticotropin receptor,Melanocortin receptor 2,MC2-R,MC2R,ACTHR,

Tissue Specificity: Melanocytes and corticoadrenal tissue.

Background: Protein diaphanous homolog 1 is a protein that in humans is encoded by the DIAPH1 gene. This gene is a homolog of the Drosophila diaphanous gene, and has been linked to autosomal dominant, fully penetrant, nonsyndromic sensorineural progressive low-frequency hearing loss. Actin polymerization involves proteins known to interact with diaphanous protein in Drosophila and mouse. It has therefore been speculated that this gene may have a role in the regulation of actin polymerization in hair cells of the inner ear. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Poids moléculaire: 150 kDa

ID gène: 1729

UniProt: O60610

Pathways: Sensory Perception of Sound